ABSTRACT
Objective To evaluate the clinical curative effect of Liuwei Nengxiao capsules combined with acupoint application for functional constipation. Methods According to the order of treatment, 105 patients with functional constipation were divided into combined treatment group, Liuwei Nengxiao group and acupoint application group with random number table, 35 cases in each group. Combined treatment group was treated with both Liuwei Nengxiao capsules orally taking and Tongbian Fang acupoint application in Shenque. Liuwei Nengxiao group was treated with Liuwei Nengxiao capsules alone, and acupoint application group was treated with Tongbian Fang acupoint application in Shenque alone. The course of treatment lasted for 10 days. The symptom scores were assessed before and after treatment, to evaluate the efficacy. Results The symptom scores of the three groups all decreased after treatment (P<0.05). The total effective rates of combined treatment group, Liuwei Nengxiao group and acupoint application group were 100%(35/35), 94.3% (33/35) and 88.6% (31/35), respectively, and the clinical effect of combined treatment group was better than that of other two groups (P<0.01). Conclusion The clinical effect of Liuwei Nengxiao capsules combined with acupoint application in treating functional constipation is superior to that of separate applications.
ABSTRACT
Glutathione S-transferases(GSTs) are a family of soluble detoxification enzymes which use reduced glutathione(GSH) in conjugation and reduction reactions.Toxic electrophiles,including a variety of carcinogens,are substrates for the GSTs and are more easily excreted into bile or urine after conjugation or reduction .The three-dimensional structures of GSTs from several species,including humans,have been determined.GST activity has been found to present in all human tissues,and expression of the various GST isoenzymes differs in degree in the various tissues. Glutathione S-transferases may play a role in the protection of cells against toxic electrophiles and in the resistance to cancer chemotherapeutic agants.The polymorphisms of GSTs genes are one of the important factors that exercise influence on individual susceptibility to cancer.
ABSTRACT
AIM: To analyse the frequencies of individuals of the GSTP1 genotypes among the Han nationality in Guangdong province. METHODS: Polymerase chain reaction-restriction fragment length polymorphism was taken to analyse the GSTP1 genotypes and identify the gene frequencies. RESULTS: The proportion of AA(Ile/Ile),AG(Ile/Val) and GG(Val/Val) genotypes were 57 4%,35 9% and 6 7%, respectively. CONCLUSION: The frequencies of individuals carrying homozygous of the GSTP1 variant allele were 6.7% among the Han nationality in Guangdong province.